J Cell Biol 109:3085–3094īannai H (2004) Kinesin dependent, rapid, bi-directional transport of ER sub-compartment in dendrites of hippocampal neurons. doi: 10.1002/dneu.20818īaas PW, Black MM, Banker GA (1989) Changes in microtubule polarity orientation during the development of hippocampal neurons in culture. doi: 10.1523/JNEUROSCI.1542-09.2009īaas PW, Lin S (2011) Hooks and comets: the story of microtubule polarity orientation in the neuron. doi: 10.1523/JNEUROSCI.4775-03.2004Īscaño M, Richmond A, Borden P, Kuruvilla R (2009) Axonal targeting of Trk receptors via transcytosis regulates sensitivity to neurotrophin responses. doi: 10.1083/jcb.200408165Īridor M (2004) Endoplasmic reticulum export site formation and function in dendrites. doi: 10.1016/j.mcn.2005.03.011Īng AL, Taguchi T, Francis S, Fölsch H, Murrells LJ, Pypaert M, Warren G, Mellman I (2004) Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cells. doi: 10.1016/j.celrep.2012.05.018Īlberi S, Boda B, Steiner P, Nikonenko I, Hirling H, Muller D (2005) The endosomal protein NEEP21 regulates AMPA receptor-mediated synaptic transmission and plasticity in the hippocampus. KeywordsĪl-Bassam S, Xu M, Wandless TJ, Arnold DB (2012) Differential trafficking of transport vesicles contributes to the localization of dendritic proteins. This chapter will discuss the basic cell biology of exocytic and endocytic traffic and lay out how the basic mechanisms are the same or are different in dendrites to accommodate the large size and spatial heterogeneity of neurons. The overall composition of the plasma membrane, which receptor is localized where and at what levels, is also regulated by spatially and temporally precise exo- and endocytosis. In addition, a large number of receptors require accurate trafficking in order to participate in localized neuronal functions. How is membrane traffic in dendrites organized to support the large size, the intricate morphology, and the spatial heterogeneity in order to create a functional neuron integrated properly into a circuit? Since dendrite form and function are disrupted when membrane traffic is disturbed, understanding membrane traffic in dendrites is important. Dendrites are often hundreds of micrometers in length, intricately branched, and studded with postsynaptic specializations. The large size of neurons poses great challenges for membrane traffic.
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